Back to results
US 6,284,779 B1Granted
Heteroaromatic compounds
AssigneesSchering Aktiiengesellschaft, Vertex Pharmaceuticals Incorporated
InventorsThomas Brumby, Fiona McDonald, Eckhard Ottow, Herbert Schneider
Life of this patent
Estimating the term…
Abstract
The invention relates to the compounds of Formula I as well as the process for their production and their use as pharmaceutical agents.
Claims20
A compound of Formula I or a physiologically compatible salt thereof,
- in which
- R1 is hydrogen, Ar, straight-chain or branched C1-C7 alkyl, which can be substituted with Ar or E, straight-chain or branched C2-C7 alkenyl, which can be substituted with Ar or E, C3-C7 cycloalkyl, which can be substituted with Ar or E, or C5-C7 cycloalkenyl, which can be substituted with Ar or E,
- Y is —(C═O)—(C═O)—, —SO2—, —(C═O)NH—, —(C═S)NH—, —(C═O)—(C═O)—O—, —(C═O)—(C═O)NH—, —(C═O)—O— or —SO2—NH—,
- R2 and R3 together with the N-atom form pyrrnlidinyl, [a 5- to 7-membered heterocycle, which can be saturated or unsaturated and] which can be substituted with C1-C4 alkyl and OH,
- X is oxadiazolyl,
- R4 is pyridinyl, straight-clhain or branched C1-C9 alkyl, straight-chain or branched C2-C9 alkenyl, C3-C7 cycloalkyl, or C5-C7 cycloalkenyl, wherein in each case the alkyl radical or the alkenyl radical is substituted with pyridinyl in one to two places, and
- Ar is a C6-C12 mono- or bicyclic aromatic compound, which optionally is partially hydrogenated and which can be substituted with E in one to three places, and
- E is halogen, hydroxy, nitro, CF3, CN, OCF3, amino, phenyl, methylenedioxy, phenoxy, benzyloxy, C1-C4 alkoxy or C1-C4 alkyl.
5 more elements
A compound of Formula IA, an isomer thereof or a physiologically compatible salt thereof
- in which,
- R1A is straight-chain or branched C1-C7 alkyl, straight-chain or branched C2-C7 alkenyl, C3-C5 cycloalkyl, C5-C7 cycloalkenyl or Ar′ optionally substituted with halogen, hydroxy, nitro, CF3, C1-C4 alkoxy or C1-C4 alkyl,
- X is oxadiazolyl,
- R4A is straight-chain or branched C1-C7 alkyl, straight-chain or branched C2-C7 alkenyl, C3-5 cycloalkyl, or C5-C7 cycloalkenyl, wherein in each case the alkyl radical or the alkenyl radical is substituted with pyridinyl in one to two places,
- r is 1, and
- Ar′ is C6-C12 aryl wherein the aryl radical is optionally substituted with halogen, hydroxy, C1-C4 alkoxy, nitro, CF3 or C1-C4 alkyl by the same or a different component in one to three places.
3 more elements
Dependencies are inferred from the claim text.