US 6,284,759 B1 · 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands

Abstract

Disclosed are compounds of the formula: or pharmaceutically acceptable salts thereof, wherein: A is (un)substituted alkylene; R1 and R2 are the same or different and represent hydrogen, halogen, alkyl, alkoxy, alkylthio, hydroxy, (un)substitutedamino, cyano, nitro, sulfonamide, trifluoromethyl or trifluoromethoxy; R3, R4, R5, R6, and R8 are independently hydrogen or alkyl; and X is sulfur, oxygen or NR7 where R8 is defined herein; m is an integer chosen from 0, 1 or 2; and Ar is an aryl or heteroaryl group as further defined herein, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.

Claims19

Dependent claims

A compound of the formula:

or a pharmaceutically acceptable salt thereof wherein;
A is C1-C6 alkylene optionally substituted with one or two C1-C6 alkyl groups;
R1 and R2 are the same or different and represent hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxy, amino, mono- or di(C1-C6)alkylamino, cyano, nitro, C1-C6 alkylsulfonyl, sulfonamido, perfluoro C1-C6 alkyl or perfluoro C1-C6 alkoxy;
R3, R4, R5, and R6 are the same or different and represent hydrogen or C1-C6 alkyl;
and
R8 is hydrogen or C1-C6 alkyl;
m is 0, 1 or 2;
and
Ar represents phenyl, naphthyl pyrimidinyl, or pyridinyl, each of which is optionally subtituted independently with up to five groups selected from C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 alkylthio, hydroxy, amino, mono- or di(C1-C6)alkylamino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-C6 alkylsulfonyl, sulfonamido, or N-alkyl sulfonamido.

6 more elements

Dependencies are inferred from the claim text.

2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands

Life of this patent

2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands

Life of this patent

Abstract

Claims19