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US 6,284,752 B1Granted
Pharmaceutical compositions comprising metal complexes
AssigneeAnorMED, Inc.
InventorsMichael J Abrams, Simon P Fricker, Barry A Murrer, Owen J Vaughan
Life of this patent
Estimating the term…
Abstract
New pharmaceutical compositions and pharmaceutical compositions comprising metal complexes have activity against diseases caused by or related to overproduction or localised high concentration of nitric oxide in the body.
Claims4
A method for preparing a pharmaceutical composition comprising formulating a neutral, anionic or cationic metal complex having at least one site for coordination with NO, of formula:
- [Ma(XbL)cYdZe]n± (formula I),
- with a pharmaceutically acceptable carrier, wherein the complex is present in an amount sufficient for attenuation of NO levels where NO is implicated in disease, and
- wherein:
- M is a metal ion or a mixture of metal ions;
- X is a cation or a mixture of cations;
- L is a ligand, or mixture of ligands each containing at least two different donor atoms selected from the elements of Group IV, Group V or Group VI of the Periodic Table;
- Y is a ligand, or a mixture of the same or different ligands each containing at least one donor atom or more than one donor atom, which donor atom is selected from the elements of Group IV, Group V or Group VI of the Periodic Table;
- and
- Z is a halide or pseudohalide ion or a mixture of halide ions and pseudohalide ions;
- a=1-3;
- b=0-12;
- c=0-18;
- d=0-18;
- e=0-18;
- and n=0-10;
- provided that at least one of c, d and e is 1 or more;
- and where c is 0;
- b is also 0;
- and where a is 1;
- c, d and e are not greater than 9;
- and where a is 2;
- c, d and e are not greater than 12.
19 more elements
Dependencies are inferred from the claim text.