Peritoneal induced medicaments

A method for combating infections of the peritoneal cavity which comprises providing to the peritoneal cavity of a mammal undergoing surgery, a solution of a medicament and an hyaluronic acid compound selected from hyaluronic acid and water-soluble salts thereof in a sterile, isotonic, flowable pharmaceutically acceptable media in which the hyaluronic acid compound is present in a concentration of at least about 0.4% by weight based on the weight of the solution, said solution having a viscosity at 25° C. of from about 500 to about 10,000 centipoise, said hyaluronic acid compound acting to retain the introduced medicament in the peritoneal cavity, the amount of solution applied being sufficient to at least coat traumatized tissue and up to an amount sufficient to coat the peritoneal cavity, said solution being applied as a single application at closing of the peritoneal cavity at the end of the operative procedure.