Immunomodulation by genetic modification of dendritic cells and B cells
AssigneeThe UAB Research Foundation
InventorsDavid T. Curiel, Bryan Walter Tillman
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Abstract
A gene delivery vector used to generate genetically modified dendritic cells and B-cells central to the immune system. As a result, genetic modification of cells bearing the CD40 target antigen on its surface can be used to modulate immunity. Previously, both dendritic cells and B-cells have been resistant to gene transfer. The present invention serves to mediate dramatic enhancements in gene transfer to these cell types. Simultaneous with gene transfer, the vector system described herein matures dendritic cells and B-cells to a more potent immunoregulatory status. This invention provides technology for genetic manipulation of dendritic cells and B-cells.
Claims6
A composition for delivery of a gene of interest to antigen presenting cells comprising:
- (a) an adenovirus encoding a gene of interest
- (b) a first antibody which specifically binds a fiber-knob protein on said adenovirus;
- and
- (c) a second antibody which specifically binds the CD40 antigen on the surface of said antigen presenting cells, wherein said first antibody and said second antibody are genetically fused to form a bispecific antibody.
Dependencies are inferred from the claim text.