Antileishmanial composition for topical application
OwnerMax Grogl, Lawrence Fleckenstein +2inventors
InventorsMax Grogl, Lawrence Fleckenstein, Patrick McGreevy, Brian Schuster
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Abstract
The instant invention provides compositions containing as active agents paromomycin in combination with gentamicin. When given in combination, the compositions appear much more effective than when given alone. Furthermore, the compositions of the invention were found to be effective against several species of Leishmania that were not effectively inhibited by the prior art compositions.
Claims14
A leishmania-inhibiting pharmaceutical composition of matter comprising an antileishmania-effective amount of paromomycin of 10% to 40% or a pharmaceutically acceptable salt thereof and an paromomycin-potentiating effective amount of gentamicin of 0.2% to 5%, or a pharmaceutically acceptable salt thereof in a pharmaceutically effective carrier.
Dependencies are inferred from the claim text.