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US 6,284,735 B1Granted
HP-3228 and related peptides to treat sexual dysfunction
AssigneeLion Bioscience AG
InventorsBeverly E. Girten, Ronald R. Tuttle
Life of this patent
Estimating the term…
Abstract
Methods for treating erectile dysfunction in males and sexual dysfunction, such as sexual arousal disorder, in females. The methods involve administering an effective dose of certain compounds, such as HP-228, having the generic formula X1-X′2-(D)Phe-Arg-(D)Trp-X3.
Claims33
A method for treating erectile dysfunction in a male subject, comprising the step of administering to the subject an effective dose of the compound
- X1-X2-(D)Phe-Arg-(D)Trp-X3
- wherein
- COCH3, H or absent;
- His, COCH3 or H;
- and
- or R5;
- wherein
- R1 is H, COCH3, C2H5, CH2Ph, COPh, COO-t-butyl, COOCH2Ph, CH2CO-(polyethylene glycol) or A;
- R2 is H, COCH3, C2H5 or CH2Ph;
- R3 is a linear alkyl group having 1 to 6 carbon atoms or a branched or cyclic alkyl group having 3 to 6 carbon atoms;
- R4 is (CH2)m—CONH2, (CH2)m—CONHR1 or (CH2)m—CONHA;
- R5 is OH, OR3, NH2, SH, NHCH3, NHCH2Ph or A;
- R6 is H or R3;
- R7 is H, COCH3, C2H5, CH2Ph, COPh, COO-t-butyl, COOCH2Ph or CH2CO-(polyethylene glycol);
- Ph is C6H5;
- m is 1, 2 or 3;
- n is 0, 1, 2 or 3;
- Y1 and Y2 are independently hydrogen atoms, or are taken together to form a carbonyl or thiocarbonyl;
- and A is
16 more elements
A method for treating sexual dysfunction in a female subject, comprising the step of administering to the subject an effective dose of the compound
- X1-X2-(D)Phe-Arg-(D)Trp-X3
- wherein
- COCH3, H or absent;
- His, COCH3 or H;
- and
- or R5;
- wherein
- R1 is H, COCH3, C2H5, CH2Ph, COPh, COO-t-butyl, COOCH2Ph, CH2CO-(polyethylene glycol) or A;
- R2 is H, COCH3, C2H5 or CH2Ph;
- R3 is a linear alkyl group having 1 to 6 carbon atoms or a branched or cyclic alkyl group having 3 to 6 carbon atoms;
- R4 is (CH2)m—CONH2, (CH2)m—CONHR1 or (CH2)m—CONHA;
- R5 is OH, OR3, NH2, SH, NHCH3, NHCH2Ph or A;
- R6 is H or R3;
- R7 is H, COCH3, C2H5, CH2Ph, COPh, COO-t-butyl, COOCH2Ph or CH2CO-(polyethylene glycol);
- Ph is C6H5;
- m is 1, 2 or 3;
- n is 0, 1, 2 or 3;
- Y1 and Y2 are independently hydrogen atoms, or are taken together to form a carbonyl or thiocarbonyl;
- and A is
16 more elements
Dependencies are inferred from the claim text.