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AssigneeDLO Instituut Voor Dierhouderij En Diergezondheid
InventorsRobert Hans Meloen, Hendrica Berendina Oonk
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The invention relates to a modified tandem LHRH-peptide vaccine preparation in which the amino acid glycine at position (6) of one or both LHRH decapeptides that constitute the tandem unit is substituted by a dextrorotatory amino acid that contains a side chain to which a carrier compound can be coupled. In addition, the tandem LHRH-peptide can be brought into a tandem-dimer form which is also suitable for producing a vaccine that is effective against LHRH (luteinizing hormone releasing hormone) also referred to as GnRH (gonadotropin-releasing hormone), for immunological castration, to inhibit or affect reproductive functions or to affect behaviour in vertebrates in general and in domesticated animals and man in particular.
A peptide comprising at least two contiguous LHRH decapeptide sequences wherein the amino acid glycine at position 6 of at least one of the constituting LHRH decapeptides is replaced by a dextrorotary amino acid with a side chain capable of coupling to a carrier compound, said peptide including an amino acid sequence comprising the structure:
A peptide that comprises at least two contiguous LHRH decapeptide sequences wherein the amino acid glycine at position 6 of at least one of the constituting LHRH decapeptides is replaced by a dextrorotary amino acid with a side chain capable of coupling to a carrier compound characterized in that it comprises an amino acid sequence comprising the structure:
Dependencies are inferred from the claim text.