Osteoprotegerin
AssigneeAmgen Inc.
InventorsWilliam J. Boyle, David L. Lacey, Frank J. Calzone, Ming-Shi Chang
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Abstract
The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
Claims9
An isolated polypeptide consisting of the amino acid sequence as shown in FIG. 9B (SEQ ID NO:6) from residues 22 to 401 inclusive.
Dependencies are inferred from the claim text.