Artemin, a novel neurotrophic factor
AssigneeWashington University
InventorsJeffrey D. Milbrandt, Robert H. Baloh
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Abstract
A novel growth factor, artemin, which belongs to the GDNF/neurturin/persephin family of growth factors, is disclosed. The human and mouse amino sequences have been identified. Human and mouse artemin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using artemin, methods for detecting artemin gene alterations and methods for detecting and monitoring patient levels of artemin are provided.
Claims5
A method for providing trophic support to a mammalian neuronal cell, or producing differentiation of the cell, or both, comprising introducing into the cell in vitro a nucleic acid comprising a nucleotide sequence encoding an artemin polypeptide of at least 96 amino acids and which has at least 75% sequence identity with SEQ ID NO:
- 19, wherein the artemin polypeptide
- comprises seven canonical framework cysteine residues,
- is naturally occurring, and
- is expressed in an amount that is effective to provide trophic support to a mammalian neuronal cell or, produce differentiation of the cell, or both.
Dependencies are inferred from the claim text.