Human DNA ligase III
AssigneeHuman Genome Sciences, Inc.
InventorsYing-Fei Wei, Guo-Liang Yu, William A. Haseltine
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Abstract
A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.
Claims22
An isolated polypeptide comprising an amino acid sequence at least 95% identical to amino acid residues 2 to 922 of SEQ ID NO:2, wherein said polypeptide has ligase activity.
An isolated polypeptide comprising amino acid residues 2 to 922 of SEQ ID NO:2.
An isolated polypeptide comprising an amino acid sequence at least 95% identical to the mature polypeptide encoded by the human cDNA contained in ATCC Deposit No. 97052, wherein said polypeptide has ligase activity.
An isolated polypeptide comprising the amino acid sequence of the mature polypeptide encoded by the human cDNA contained in ATCC Deposit No. 97052.
Dependencies are inferred from the claim text.