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AssigneeWhitehead Institute for Biomedical Research
InventorsAndreas Stahl, David J. Hirsch, Harvey F. Lodish
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A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ.
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid which hybridizes to a nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid encoding a fusion polypeptide, wherein the isolated nucleic acid comprises the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid which hybridizes to a nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid encoding a fusion polypeptide, wherein the isolated nucleic acid comprises the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid which hybridizes to a nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid encoding a fusion polypeptide, wherein the isolated nucleic acid comprises the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid which hybridizes to a nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid encoding a fusion polypeptide, wherein the isolated nucleic acid comprises the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid which hybridizes to a nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid encoding a fusion polypeptide, wherein the isolated nucleic acid comprises the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid which hybridizes to a nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid encoding a fusion polypeptide, wherein the isolated nucleic acid comprises the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid which hybridizes to a nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid encoding a fusion polypeptide, wherein the isolated nucleic acid comprises the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid which hybridizes to a nucleic acid comprising the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO.:
An isolated nucleic acid which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO.:
An isolated nucleic acid encoding a fusion polypeptide, wherein the isolated nucleic acid comprises the nucleotide sequence of SEQ ID NO.:
Dependencies are inferred from the claim text.