Nucleic acids encoding osteoprotegerin
AssigneeAmgen Inc.
InventorsWilliam J. Boyle, David L. Lacey, Frank J. Calzone, Ming-Shi Chang
Life of this patent
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Abstract
The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
Claims16
An isolated nucleic acid encoding a polypeptide having the biological activity of inhibiting bone resorption and comprising a derivative of the amino acid sequence 22 to 401 as shown in FIG. 9B (SEQ ID NO:6) which differs from amino acid residues 22 to 401 of SEQ ID NO:6 by deletion or carboxy-terminal truncation of part or all of amino acid residues 180 to 401.
An isolated nucleic acid encoding a polypeptide having the biological activity of inhibiting bone resorption and comprising a derivative of the amino acid sequence 1 to 401 as shown in FIG. 9B (SEQ ID NO:6) which differs from amino acid residues 1 to 401 of SEQ ID NO:6 by deletion or carboxy-terminal truncation of part or all of amino acid residues 180 to 401.
An isolated nucleic acid encoding a polypeptide having the biological activity of inhibiting bone resorption and comprising a derivative of the amino acid sequence 22 to 401 as shown in either FIG. 2B (SEQ ID NO:2) or 9A (SEQ ID NO:4) which differs from amino acid residues 22 to 401 of SEQ ID NO:2 or SEQ ID NO:4 by deletion or carboxy-terminal truncation of part or all of amino acid residues 180 to 401.
An isolated nucleic acid encoding a polypeptide having the biological activity of inhibiting bone resorption and comprising a derivative of the amino acid sequence 1 to 401 as shown in either FIG. 2B (SEQ ID NO:2) or 9A (SEQ ID NO:4) which differs from amino acid residues 1 to 401 of SEQ ID NO:2 or SEQ ID NO:4 by deletion or carboxy-terminal truncation of part or all of amino acid residues 180 to 401.
The nucleic acid of claims Korfwherein the polypeptide is fused to an Fc region of human IgG or to a derivative of an Fc region of human IaG.
Dependencies are inferred from the claim text.