Method for detection of abnormal keratinization in epithelial tissue
AssigneeOralscan Laboratories, Inc.
InventorsDrore Eisen, Stephen Frist, Joel Recht
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Abstract
A sample of an epithelial lesion which may be keratinized is disclosed in which an analytical system including an imaging system is provided to detect precancerous and cancerous cells. A transepithelial non-lacerational brush produces sufficient cells from all three layers of the epithelium so that an analytical system comprising a programmed computer can detect which cells exhibit abnormal keratinization and require further examination because of a likely suspicion of said pre-cancerous and cancerous conditions. The method and system can apply to the diagnosis non-cancerous conditions as well.
Claims26
A method to detect abnormal cells in sample cells of epithelial tissue of the body, such sample cells having been collected by non-lacerational techniques collecting said sample cells from among the superficial, intermediate and basal layers of said epithelial tissue, wherein said method analyzes the sample cells, said method comprising:
- using a computer to detect and display selected cells of said sample cells,
- analyzing the selected cells collected to detect abnormally keratinized cells,
- wherein said epithelial tissue is oral mucosa,
- said method includes the step of analyzing the sample cells to determine if cells have been collected from the basal layer, further including that if no abnormal cells are detected, the step of determining that if cells have not been collected from said basal layer that the detection of abnormal cells was incomplete and the analysis should be disregarded.
Dependencies are inferred from the claim text.