Diagnostic method of use of OMP26 antigen from Haemophilus influenzae
AssigneeProvalis UK Limited
InventorsJennelle Kyd, Allan Cripps, Christopher John Smith
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Abstract
A novel antigenic protein derived from the outer membrane of H. influenzae is provided. DNA sequences encoding such a protein are also provided as are vaccines comprising the protein and methods of immunising a subject against H. influenzae infection. The invention also includes methods for the prophylaxis or treatment of rerspiratory tract infections or otitis media, as well as methods for the detection of H. influenzae, and kits for use in such methods.
Claims10
A method for the diagnosis of H. influenzae infection, comprising the step of contacting a sample from a subject with an isolated protein which (i) is an outer membrane protein of H. influenzae or an immunogenic fragment thereof, and (ii) comprises the amino acid sequence as set forth in SEQ ID No. 2, an immunogenic fragment of said sequence, a sequence at least 90 identical to the amino acid sequence as set forth in SEQ ID NO. 2 and having an immunogenic epitope of said sequence of SEQ ID NO:
- 2, or an immunogenic fragment of a sequence at least 90% identical to the amino acid sequence as set forth in SEQ ID No. 2 and having an immunogenic epitope of said sequence of SEQ ID NO:
- 2, and detecting a specific binding interaction with antibody in said sample, in which said interaction indicates the presence of H. influenzae.
A method for the diagnosis of H. influenzea infection, comprising the step of contacting a sample from a subject with an isolated protein which (i) is an outer membrane protein of H. influenzae or an immunogenic fragment thereof, and (ii) comprises the amino acid sequence as set forth in SEQ ID No. 2 commencing with amino acid twenty-four as the N-terminal amino acid, an immunogenic fragment of said sequence, a sequence at least 90% identical to the amino acid sequence as set forth in SEQ ID NO. 2 commencing with amino acid twenty-four as the N-terminal amino acid and having an immunogenic epitope of said sequence of SEQ ID NO:
- 2 commencing with amino acid twenty-four or an immunogenic fragment of a sequence at least 90% identical to the amino acid sequence as set forth in SEQ ID No. 2 commencing with amino acid twenty-four as the N-terminal amino acid and having an immunogenic epitope of said sequences of SEQ ID NO:
- 2 commencing with amino acid twenty-four, and detecting a specific binding interaction with antibody in said sample, in which said interaction indicates the presence of H influenzae.
A method for the diagnosis of H. influenzea infection, comprising the step of contacting a sample from a subject with an isolated protein which is an outer membrane protein of Haemophilus influenzae and comprises the amino acid sequence as set forth in SEQ ID NO. 2 or an immunogenic fragment of said sequence, and detecting a specific binding interaction with antibody in said sample, in which said interaction indicates the presence of H. influenzae.
Dependencies are inferred from the claim text.