Methods of using plasma expanders and blood substitutes
AssigneeBioTime, Inc.
InventorsPaul E. Segall, Harold D. Waitz, Hal Sternberg, Judith M. Segall
Life of this patent
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Abstract
A blood substitute solution and methods for its use are provided. The subject solution contains: subphysiological amounts of potassium ion, 0-10 mM magnesium ion, 70-160 mM sodium ion, 0.5-4.0 mM calcium ion, and 80-170 mM chloride ion; one or more water soluble oncotic agents; an organic carboxylic acid or salt thereof; physiological amounts of a sugar; and a blood clotting factor. The subject solution is further characterized in that it does not include a conventional biological buffer. The subject solutions find use in a variety of different applications, e.g. as blood volume expanders, and the like.
Claims12
A method for increasing the circulating volume of a hypovolemic subject, the method comprising:
- administering to said subject an aqueous solution comprising:
- (a) a subphysiological amount of potassium ion,
- (b) 0-10 mM magnesium ion,
- (c) 70-160 mM sodium ion,
- (d) 0.5-4.0 mM calcium ion,
- (e) 80-170 mM chloride ion;
- (f) one or more water soluble oncotic agents;
- (g) an organic carboxylic acid or salt thereof;
- (h) physiological amounts of a sugar;
- and
- (i) a blood clotting factor;
- with the proviso that said solution does not contain a conventional biological buffer.
A method for substituting the circulating blood of a subject, the method comprising:
- administering to said subject an aqueous solution comprising:
- (a) a subphysiological amount of potassium ion,
- (b) 0-10 mM magnesium ion,
- (c) 70-160 mM sodium ion,
- (d) 0.5-4.0 mM calcium ion,
- (e) 80-170 mM chloride ion;
- (f) one or more water soluble oncotic agents;
- (g) an organic carboxylic acid or salt thereof;
- (h) physiological amounts of a sugar;
- and
- (i) a blood clotting factor;
- with the proviso that said solution does not contain a conventional biological buffer.
Dependencies are inferred from the claim text.