US 6,284,283 B1 · Method of producing sub-micron particles of biologically active agents and uses thereof

Abstract

Submicron particles of a biologically active agent are prepared by atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent to produce droplets, freezing the droplets to produce frozen droplets, lyophilizing the frozen droplets to obtain microstructures capable of being further fragmented into submicron particles by techniques such as probe sonication. The submicron particles can be incorporated into sustained release compositions having a reduced initial release of biologically active agent. The sustained release compositions can be administered to a human or animal.

Claims36

Dependent claims

A method for preparing submicron particles of a biologically active agent comprising the steps of:

(a) atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent at a mass flow ratio of about 0.30 or greater to produce droplets;
(b) freezing the droplets to produce frozen droplets;
(c) removing the solvent from the frozen droplets to produce friable microstructures;
(d) forming a dispersion of the friable microstructures with at least one non-solvent for the biologically active agent;
and
(e) fragmenting the dispersed friable microstructures into submicron particles of biologically active agent.

3 more elements

Dependencies are inferred from the claim text.

Method of producing sub-micron particles of biologically active agents and uses thereof

Life of this patent

Method of producing sub-micron particles of biologically active agents and uses thereof

Life of this patent

Abstract

Claims36