Amphiphilic materials and liposome formulations thereof
AssigneeNutrimed Biotech
InventorRajindra Aneja
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Abstract
Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.
Claims57
An amphiphilic molecule comprising a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus of said hydrophilic component.
An amphiphilic molecule comprising a hydrophilic component having covalently attached, at spatially distant sites, at least two hydrophobic moieties, said amphiphilic molecule forming a liquid-crystalline multimolecular aggregate upon contact of a number of said amphiphilic molecules with an aqueous solution, wherein the mesophases of said liquid-crystalline multimolecular aggregates, as characterized by X-ray diffraction, include the fluid Lα, gel Lβ, and hexagonal mesophases.
A method of making an amphiphilic molecule, comprising separately attaching at least a first and second hydrophobic moieties to, or proximal to, the first and second terminus of a hydrophilic component.
An amphiphilic molecule comprising a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus of said hydrophilic component;
- wherein said amphiphilic molecule forms a liquid-crystalline multimolecular aggregate upon contact of a number of said amphiphilic molecules with an aqueous solution, wherein the mesophases of said liquid-crystalline multimolecular aggregates, as characterized X-ray diffraction, include the fluid Lα, gel Lβ, and hexagonal mesophases.
An amphiphilic molecule comprising a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus of said hydrophilic component;
- wherein said amphiphilic molecule forms a micellar or lamellar mesophase upon interaction of a number of said amphiphilic molecules with an aqueous medium.
An amphiphilic molecule comprising a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus of said hydrophilic component;
- wherein said first and second hydrophobic moieties are selected from Table 2.
Dependencies are inferred from the claim text.