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US 6,284,246 B1Granted
Modified polypeptides with high activity and reduced allergenicity
AssigneeThe Procter & Gamble Company
InventorsDavid J. Weisgerber, Donn N. Rubingh
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AssigneeThe Procter & Gamble Company
InventorsDavid J. Weisgerber, Donn N. Rubingh
Estimating the term…
The present invention relates to a modified polypeptide which has an enzymatic activity level of greater than about 70% of the parent polypeptide and an allergenic response level of less than about 33% of the parent polypeptide. Embodiments of the present invention relate to modified polypeptides with reduced allergenicity and high enzymatice activity comprising the formula: A-Bn wherein A is an enzyme, and mixtures thereof; B is a twin polymer moiety, having a total molecular weight of from about 0.5 kilodaltons (KD) to about 40 KD, having the formula conjugated to the enzyme; wherein R1 and R2 are essentially straight chain polymers, having a molecular weight ranging from about 0.25 KD to about 20 KD; wherein the ratio of the molecular weights of R1 and R2 is from about 1:10 to about 10:1; wherein X is a linking moiety which links the twin moeity to a single site on the enzyme; and n is the number of twin polymer moietis conjugated to the enzyme, and represents an integer from about 1 to about 15.
A modified polypeptide which has an enzymatic activity level of greater than about 70% of a parent polypeptide and an allergenic response level of less than about 33% of the parent polypeptide, wherein the parent polypeptide comprises an enzyme with no additional conjugation of polymer moieties.
A modified polypeptide with reduced allergenicity and high activity comprising the formula:
A modified polypeptide with reduced allergenicity and high activity comprising the formula:
Dependencies are inferred from the claim text.