Method for enhancing myoblast migration and invasion in the context of gene therapy
AssigneeThe Regents of the University of Michigan
InventorKotoku Kurachi
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Abstract
A novel, empirically derived composition of cytokines and myoblasts is described, that allows for the migration of myoblasts through connective barriers, along with methods employing the composition in the in vivo migration of myoblasts for therapeutic purposes and gene therapy, as well as methods for the identification of agents that are agonistic or antagonistic to myoblast migration in vitro or in vivo.
Claims20
A composition, comprising isolated myoblasts co-transfected with a gene encoding a metalloprotease and a gene encoding a marker protein to detect cell migration and invasion.
A composition, comprising a mixture comprising a first population of isolated myoblasts, said first population of myoblasts transfected with a gene encoding a metalloprotease, and a second population of isolated myoblasts, said second population transfected with a gene encoding a marker protein to detect cell migration and invasion.
Dependencies are inferred from the claim text.