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US 6,284,239 B1Granted
Murine model for human carcinoma
AssigneeCorixa Corporation
InventorsElizabeth Repasky Subjeck, Heather Sechrist, Harvey L. Bumpers
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Abstract
A murine model for human breast, ovarian and prostate cancer is provided. The model comprises either an immunodeficient mouse containing human primary breast, ovarian or prostate carcinoma tissue implanted within the gonadal fat pad, or an immunodeficient mouse containing human prostate or ovarian carcinoma tissue subcutaneously implanted therein. Methods of using the murine model, for example, to grow tumors and to screen treatments for breast, ovarian and/or prostate cancer are also provided.
Claims7
A method of evaluating the effectiveness of a breast cancer therapy, comprising:
- (a) implanting a specimen of a human breast carcinoma within a gonadal fat pad of an immunodeficient mouse, wherein the mouse lacks functional T cells;
- (b) removing a portion of the implanted carcinoma specimen;
- (c) subsequently implanting the portion within a gonadal fat pad of a second immunodeficient mouse;
- (d) exposing the second immunodeficient mouse to a candidate therapy;
- and
- (e) determining a change in size of the implanted specimen, the extent of tumor cell death and/or the level of metastatic spread in the mouse, and therefrom determining the effectiveness of the candidate therapy.
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Dependencies are inferred from the claim text.