Topical delivery systems for active agents
AssigneeJohnson & Johnson Consumer Companies, Inc.
InventorsSusan M. Niemiec, Jonas C. T. Wang, Stephen J. Wisniewski, Kurt S. Stenn, Gwang Wei Lu
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Abstract
This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.
Claims25
A micellar composition for enhancing the topical application of a skin or hair benefit agent comprising, based upon the total weight of the composition:
- A. from about 1 percent to about 10 percent of a nonionic lipid selected from the group consisting of:
- i. glyceryl monoesters having a fatty acid chain containing from about 3 to about 50 carbon atoms;
- ii. glyceryl diesters having a fatty acid chain containing from about 5 carbon atoms to about 25 carbon atoms;
- iii. alkoxylated alcohols alkoxylated with ethylene oxide or propylene oxide;
- iv. alkoxylated alkyl phenols alkoxylated with ethylene oxide or propylene oxide;
- v. alkoxylated acids alkoxylated with ethylene oxide or propylene oxide;
- vi. alkoxylated amides alkoxylated with ethylene oxide or propylene oxide;
- vii. alkoxylated sugar derivatives alkoxylated with ethylene oxide or propylene oxide;
- viii. alkoxylated derivatives of natural oils or waxes alkoxylated with ethylene oxide or propylene oxide;
- ix. polyoxyethylene fatty ethers having a fatty acid chain containing from about 10 carbon atoms to about 18 carbon atoms;
- x. steroids;
- xi. fatty acid esters of alcohols where the fatty acid is straight or branched chain having from about 10 carbon atoms to about 20 carbon atoms and the alcohol is straight or branched chain having 1 to 10 carbon atoms;
- and
- xii. mixtures thereof;
- B. from about 74 percent to about 98 percent of a vehicle comprised of:
- 1) a first vehicle component comprised of water;
- and
- 2) a second vehicle component comprised of an alcohol, a polyol, or mixtures thereof;
- and
- C. an effective amount of the skin or hair benefit agent,
- wherein said micelle is comprised of said nonionic lipid and said second vehicle component.
A micellar topical delivery system for skin or hair benefit agents comprising, based upon the total weight of the delivery system:
- A. from about 0.5 percent to about 10 percent of a nonionic lipid selected from the group consisting of:
- i. glyceryl monoesters having a fatty acid chain containing from about 3 to about 50 carbon atoms;
- ii. glyceryl diesters having a fatty acid chain containing from about 5 carbon atoms to about 25 carbon atoms;
- iii. alkoxylated alcohols alkoxylated with ethylene oxide or propylene oxide;
- iv. alkoxylated alkyl phenols alkoxylated with ethylene oxide or propylene oxide;
- v. alkoxylated acids alkoxylated with ethylene oxide or propylene oxide;
- vi. alkoxylated amides alkoxylated with ethylene oxide or propylene oxide;
- vii. alkoxylated sugar derivatives alkoxylated with ethylene oxide or propylene oxide;
- viii. alkoxylated derivatives of natural oils or waxes alkoxylated with ethylene oxide or propylene oxide;
- ix. polyoxyethylene fatty ethers having a fatty acid chain containing from about 10 carbon atoms to about 18 carbon atoms;
- x. steroids;
- xi. fatty acid esters of alcohols where the fatty acid is straight or branched chain having from about 10 carbon atoms to about 20 carbon atoms and the alcohol is straight or branched chain having 1 to 10 carbon atoms;
- and
- xii. mixtures thereof;
- B. from about 74 percent to about 99.5 percent of a vehicle comprised of:
- 3) a first vehicle component comprised of water;
- and
- 4) a second vehicle component comprised of an alcohol, a polyol, or mixtures thereof,
- wherein said micelle is comprised of said nonionic lipid and said second vehicle component.
Dependencies are inferred from the claim text.