Inhibitory effect of synthetic and natural colorants on carcinogenesis
OwnerGovind J. Kapadia, Harunkuni Tokoda +3inventors
InventorsGovind J. Kapadia, Harunkuni Tokoda, Takao Konoshima, Midori Takasaki, Hoyoku Nishino
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Abstract
A method of treating a group of mammals which have been topically exposed to a tumor promoter or a tumor initiator so as to reduce the percentage of mammals which exhibit formation of epidermal tumors. The topically exposed tissue is treated with an acetone solution containing a defined amount of a synthetic colorant. Preferably, the synthetic colorant is tartrazine or erythrosine B.
Claims10
A method of treating a group of mammals so as to reduce the percentage of mammals which exhibit tumor formation in epidermal tissue, wherein said mammals have been topically exposed to a chemical substance selected from the group consisting of tumor promoters and tumor initiators, said method comprising the steps of:
- obtaining a group of mammals having epidermal tissue which has been topically exposed to a defined amount of a chemical substance selected from the group consisting of tumor promoters and tumor initiators;
- and
- treating the epidermal tissue topically with an acetone solution containing a defined amount of a synthetic colorant, said defined amount of said synthetic colorant being effective to reduce a percentage of mammals in said group of mammals which exhibit tumor formation in said epidermal tissue, wherein said synthetic colorant is a compound selected from the group consisting of tartrazine and erythrosine B;
- wherein said defined amount of said chemical substance is sufficient to increase the incidence of epidermal tumor formation in a group of animals having epidermal tissue which has been topically exposed to the chemical substance, but which has not been topically treated with the synthetic colorant.
A method of treating a group of mammals so as to reduce the percentage of mammals which exhibit tumor formation in epidermal tissue, wherein said mammals have been topically exposed to a chemical substance selected from the group consisting of tumor promoters and tumor initiators, said method comprising the steps of:
- obtaining a group of mammals having epidermal tissue which has been topically exposed to a defined amount of a tumor initiator, and then has been topically exposed to a defined amount of a tumor promoter, and
- treating the epidermal tissue topically with an acetone solution containing a defined amount of a synthetic colorant, said defined amount of said synthetic colorant being effective to reduce a percentage of mammals in said group of mammals which exhibit tumor formation in said epidermal tissue, wherein said synthetic colorant is a compound selected from the group consisting of tartrazine and erythrosine B;
- wherein said defined amount of said tumor initiator and said defined amount of said tumor promoter are in combination sufficient to increase the incidence of epidermal tumor formation in a group of animals having epidermal tissue which has been topically and sequentially exposed to the tumor initiator and to the tumor promoter, but which has not been topically treated with the synthetic colorant.
Dependencies are inferred from the claim text.