Apparatus and method for removing small molecules and ions from low volume biological samples

An apparatus for lowering the ionic strength of a low volume solution used in

• the electronic transport of nucleic acids, proteins, and/or cells comprising:
• a tubular molecular weight cut-off membrane having a lumen, ion exchange resin, electrodialysis electrodes, and a chamber surrounding and housing said membrane, electrodialysis electrodes, and resin wherein said membrane has an entrance and an exit port leading through said chamber, said membrane further embedded in and amongst said resin, said chamber having entrance and exit ports for exchanging a flowable material into and out of said chamber, and said electrodes are positioned in a spaced axial alignment and on opposing sides of said chamber with respect to said membrane.