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US 6,281,376 B1Granted
Therapeutic compound—fatty acid conjugates
AssigneeCommonwealth Scientific and Industrial Research Organisation
InventorsRobert George Whittaker, Veronika Judith Bender, Wayne Gerrard Reilly, Minoo Moghaddam
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Abstract
A therapeutic compound of the chlorambucil family conjugated to two or three acyl groups derived from fatty acids. The compound has the following formula. in which X is chlorambucil, Y is an optional spacer group, AA is an amino acid, B is H or CH2O—R3, and n is a number from 0 to 3. X is linked to Y via the carboxyl group. R1, R2 and R3 are as defined by the present specification.
Claims2
A compound of the following formula:
- in which X is chlorambucil and is linked to Y via the carboxyl group
- Y is an optional spacer group
- AA is an amino acid;
- n is a number from 0 to 5
- B is H or CH2O—R3
- R1, R2 and R3 are the same or different and are either hydrogen, methyl, ethyl or an acyl group derived from a fatty acid, with the proviso that at least one of R1, R2 and R3 is an acyl group derived from a fatty acid.
3 more elements
Dependencies are inferred from the claim text.