Cyclic hydrazine derivatives

A hydrazine derivative, being a compound of the formula

• wherein the ring incorporating W, X, Y, and Z is selected from the group consisting of rings of formulae (a), (b), (c), (d), (e), (f), (g), (h), (i), (u),
• and
• R1 is unsubstituted lower alkyl, unsubstituted lower alkenyl, unsubstituted lower cycloalkyl, unsubstituted lower cycloalkyl-lower alkyl, unsubstituted or substituted phenyl or naphthyl, or phenyl- or naphthyl-lower alkyl in which the phenyl or naphthyl is unsubstituted or substituted and the lower alkyl is unsubstituted;
• R2 is unsubstituted lower alkyl, unsubstituted lower alkenyl, unsubstituted lower cycloalkyl, unsubstituted lower cycloalkyl-lower alkyl, —V-phenyl or -naphthyl in which the phenyl or naphthyl is unsubstituted or substituted, —V-heterocyclyl in which the heterocyclyl is unsubstituted or substituted, or —(CH2)q—CH═CR8R9;
• R3, R4, R5, R6 and R7 are each independently hydrogen, unsubstituted or substituted lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl in which the lower alkyl is unsubstituted and the cycloalkyl is unsubstituted, unsubstituted or substituted phenyl or naphthyl, phenyl- or naphthyl-lower alkyl in which the phenyl or naphthyl is unsubstituted or substituted and the lower alkyl is unsubstituted, unsubstituted or substituted heterocyclyl or heterocyclyl-lower alkyl in which the heterocyclyl is unsubstituted or substituted and the lower alkyl is unsubstituted;
• except that R3 and R4 cannot both be hydrogen, or R3 and R4 together with the carbon atom to which they are attached form a saturated carbocyclic ring having from 3 to 8 ring atoms in which zero or one ring atom is a heteroatom selected from the groups consisting of N, O and S wherein the ring nitrogen is unsubstituted or substituted;
• or R5 and R6 or R5 and R7 together with the nitrogen atoms to which they are attached form a saturated carbocyclic ring having from 3 to 8 ring atoms;
• or R11 and R12 together with the sp2 carbon atoms to which they are attached form a fused unsubstituted lower cycloalkenyl, unsubstituted or substituted phenyl or naphthyl or unsubstituted or substituted heteroaryl;
• or R5 with either R13 or R14 together are lower alkylene in which zero or one CH2 of the lower alkylene is replaced by a heteroatom selected from the group consisting of N, O and S wherein the N is unsubstituted or substituted;
• or either R6 or R7 with either R3 or R4 together are lower alkylene in which zero or one CH2 of the lower alkylene is replaced by a heteroatom selected from the group consisting of N, O and S wherein the N is unsubstituted or substituted;
• V is —(CH2)r—U—(CH2)s— in which r and s are each independently 0, 1, 2 or 3 and wherein U is absent or is —CH═CH—, —C≡C—, —S—, —O—, —NH—, NHCO—, —CONH—, —SO2—, —NHSO2—, —SO2NH—, —NHCONH— or —NHSO2NH—;
• R8 and R9 together are lower alkylene in which zero or one CH2 of the lower alkylene is replaced by a heteroatom selected from the group consisting of N,O and S wherein the N is unsubstituted or substituted;
• and
• q is 1 or 2;
• or a mixture containing the compound and one or more optical isomers thereof, or a pharmaceutically acceptable salt of said compound or said mixture.