Aminomethyl phenyl pyridine derivatives
AssigneeNeurogen Corporation
InventorsJun Yuan, Andrew Thurkauf
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds of the formula: where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR′ where R′ is an organic or inorganic substituent; R is hydrogen or an alkyl group; R1, X, Y, Z and T are organic or inorganic substituents; and R2 and R3 represent hydrogen or organic substituents; or NR2R3 together represents a heterocyclic ring system; and the pharmaceutically acceptable salts thereof; which are highly selective partial agonists or antagonists at brain dopamine receptor subtypes and, thus, are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.
Claims3
A compound of the formula:
- or a pharmaceutically acceptable salt thereof wherein:
- S and V are the same or different and represent hydrogen, halogen, hydroxy, phenyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
- G and K represent N or CR′ where R′ is hydrogen, halogen, straight or branched chain lower alkyl having 1-6 carbon atoms or straight or branched lower alkoxy having 1-6 carbon atoms, provided that one and only one of G and K is nitrogen;
- R is hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms;
- R1, X, Y, Z and T are the same or different and represent hydrogen, halogen, cyano, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms or SO2R4 where R4 is straight or branched chain lower alkyl having 1-6 carbon atoms or where R4 is NH2 or NHCH3;
- NR2R3 represents
- where W is N;
- and
- R6 is phenyl, benzyl, pyridyl or pyrimidinyl, unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
- and
- n is 1, 2 or 3.
A compound of the formula:
- or the pharmaceutically acceptable salts thereof wherein:
- S and V are the same or different and represent hydrogen, halogen, hydroxy, phenyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
- R′ is hydrogen, halogen, straight or branched chain lower alkyl having 1-6 carbon atoms or straight or branched lower alkoxy having 1-6 carbon atoms;
- R is hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms;
- R1, X, Y, Z and T are the same or different and represent hydrogen, halogen, cyano, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms or SO2R4 where R4 is straight or branched chain lower alkyl having 1-6 carbon atoms or where R4 is NH2 or NHCH3;
- NR2R3 represents
- where W is N;
- and
- R6 is phenyl, benzyl, pyridyl or pyrimidinyl, unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
- and n is 1, 2 or 3.
A compound of the formula:
- or the pharmaceutically acceptable salts thereof wherein:
- S and V are the same or different and represent hydrogen, halogen, hydroxy, phenyl, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
- R′ is hydrogen, halogen, straight or branched chain lower alkyl having 1-6 carbon atoms or straight or branched lower alkoxy having 1-6 carbon atoms;
- R is hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms;
- R1, X, Y, Z and T are the same or different and represent hydrogen, halogen, cyano, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms or SO2R4 where R4 is straight or branched chain lower alkyl having 1-6 carbon atoms or where R4 is NH2 or NHCH3;
- NR2R3 represents
- where W is N;
- and
- R6 is phenyl, benzyl, pyridyl or pyrimidinyl, unsubstituted or mono or disubstituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
- and n is 1, 2 or 3.
Dependencies are inferred from the claim text.