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US 6,281,356 B1Granted
Substituted pyrroles
AssigneeHoffmann-La Roche Inc.
InventorsNader Fotouhi, Norman Kong, Allen John Lovey
Life of this patent
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Abstract
Disclosed are substituted pyrroles having the formula These compounds and their pharmaceutically acceptable salts are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds.
Claims87
A compound of the formula
- wherein
- R1 and R2 are independently hydrogen or lower alkyl, lower alkenyl or lower alkynyl;
- R2 is hydrogen nitro, cyano, halogen, lower alkyl, lower alkenyl, lower alkynyl, or lower alkoxy;
- and
- R2′ is a heteroaryl, heterocycle, ethyl substituted with a heteroaryl, or ethoxy substituted with a heteroaryl or heterocycle;
- or
- a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.