Proteins associated with apoptosis
AssigneeIncyte Genomics, Inc.
InventorsJennifer L. Hillman, Henry Yue, Pretti Lal, Purvi Shah, Neil C. Corley
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Abstract
The invention provides three human proteins associated with cell proliferation, referred to collectively as “APOP” and individually as “APOP-1”, “APOP-2”, and “APOP-3”, and polynucleotides which identify and encode APOP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of APOP.
Claims8
A purified polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) SEQ ID NO:3, SEQ ID NO:5, and
- b) a fragment of SEQ ID NO:3 consisting of at least fifteen contiguous amino acid residues from about amino acid residue A309 to about amino acid residue G440 of SEQ ID NO:3.
A purified protein associated with apoptosis having at least 90% amino acid identity over the complete sequence of the amino acid sequence of SEQ ID NO:3 or SEQ ID NO:5, and which possesses apoptosis activity.
Dependencies are inferred from the claim text.