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AssigneeThe Salk Institute of Biological Studies
InventorsRonald M. Evans, Michael B. Mc Keown, Anthony E. Oro, William A. Segraves, Tso-Pang Yao
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In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
An isolated multimeric receptor, wherein at least one subunit of said multimeric receptor is an ultraspiracle receptor, and wherein at least one subunit of said multimeric receptor is a hormone binding protein, wherein said hormone binding protein is characterized by having a DNA-binding domain having the amino acid sequence set forth in SEQ ID NO:3.
An isolated multimeric receptor comprising a first subunit and a second subunit, wherein said first subunit is an ultraspiracle receptor and wherein said second subunit is a non-insect member of the steroid/thyroid hormone superfamily of receptors.
Dependencies are inferred from the claim text.