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US 6,281,257 B1Granted
Porous composite materials
AssigneeThe Regents of the University of Michigan
InventorsPeter X. Ma, Ruiyun Zhang
Life of this patent
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Abstract
Methods and compositions are described that provide three dimensional porous matrices as structural templates for cells. The porous matrices of the present invention have desirable mechanical properties suitable to a variety of applications, including platforms for in vitro cell cultivation, implants for tissue and organ engineering, and materials suitable for chromatography and filtration.
Claims21
A method, comprising:
- a) providing:
- i) a polymer source,
- ii) an inorganic compound, and
- iii) a solvent solution having a freezing temperature below room temperature;
- b) mixing said polymer with said solvent solution to create a polymer solution above room temperature;
- c) adding said inorganic compound to said polymer solution to create a mixture in a container;
- d) placing said container at a temperature below said freezing temperature of said solvent solution so as to create a solidified matrix;
- and
- e) treating said solidified matrix under conditions whereby a solvent free matrix is created having a porosity greater than approximately 80%.
6 more elements
A method, comprising:
- a) providing:
- i) a polymer source,
- ii) an inorganic compound, and
- iii) a solvent solution comprising dioxane;
- b) mixing said polymer with said solvent to create a polymer solution;
- c) adding said inorganic compound to said polymer solution to create a mixture in a container;
- d) placing said container at a temperature below dioxane's melting point;
- and
- e) freezing said solvent in said mixture to create a frozen mixture;
- f) treating said frozen mixture under conditions whereby a solvent free matrix is created having a porosity greater than approximately 80%.
7 more elements
A method, comprising:
- a) providing:
- i) a polymer source,
- ii) a solvent, and
- iii) a simulated body fluid;
- b) mixing said polymer with said solvent to create a homogenous polymer solution;
- c) subjecting said mixture to such conditions whereby a solvent free matrix is created;
- d) contacting said solvent free matrix with said simulated body fluid.
4 more elements
A method, comprising:
- a) providing:
- i) a polymer source,
- ii) an inorganic compound, and
- iii) a solvent solution comprising benzene;
- b) mixing said polymer with said solvent solution to create a polymer solution;
- c) adding said inorganic compound to said polymer solution to create a mixture in a container;
- d) placing said container at a temperature below benzene's melting point so as to create a solidified matrix;
- and
- e) treating said mixture under conditions whereby a solvent free matrix is created having porosity greater than approximately 80%.
6 more elements
Dependencies are inferred from the claim text.