Open pore biodegradable matrices
AssigneeThe Regents of the University of Michigan
InventorsLeatrese Harris, David J. Mooney, Lonnie Shea
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Abstract
The invention is directed to a process for preparing porous polymer materials by a combination of gas forming and particulate leaching steps. The invention is also directed to porous polymer material prepared by the process, particularly having a characteristic interconnected pore structure, and to methods for using such porous polymer material, particularly for tissue engineering.
Claims36
A process for preparing a porous polymer material which comprises forming pores in a polymer material which contains a leachable particulate by foaming and subsequently leaching out the particulate material to form additional porosity wherein the polymer material comprises a homopolymer of a lactic acid or glycolic acid, a copolymer of a lactic acid and glycolic acid, an aliphatic polyester, a polyanhydride, a polyphosphazine, a polypeptide, a blend of a copolymer of a lactic acid and glycolic acid with an alginate, or any combination of the above materials.
A porous polymer comprising a polymer matrix containing pores formed by gas foaming and pores formed by leaching out of a particulate from the polymer wherein the polymer material comprises a homopolymer of a lactic acid or glycolic acid, a copolymer of a lactic acid and glycolic acid, an aliphatic polyester, a polyanhydride, a polyphosphazine, a polypeptide, a blend of a copolymer of a lactic acid and glycolic acid with an alginate, or any combination of the above materials.
A polymer material which comprises a section of porous polymer comprising a polymer matrix containing pores formed by gas foaming and pores formed by leaching out of a particulate from the polymer and a section of impermeable polymer integrally connected wherein the polymer material comprises a homopolymer of a lactic acid or glycolic acid, a copolymer of a lactic acid and glycolic acid, an aliphatic polyester, a polyanhydride, a polyphosphazine, a polypeptide, a blend of a copolymer of a lactic acid and glycolic acid with an alginate, or any combination of the above materials.
Dependencies are inferred from the claim text.