Method of treating onychomycosis
AssigneeBradley Pharmeaceuticals, Inc.
InventorDaniel Glassman
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Abstract
A method of treating onychomycosis is described which includes administration to an infected area around a nail of a patient a tissue softening composition containing urea and an antifungal composition in one or separate compositions, concurrently or non-concurrently. Also described is a kit which contains the unit dosage forms, a protective gel and appropriate dressings for ready application.
Claims12
A topical antifungal composition for treating onychomycosis consisting essentially of up to 5 wt.% of an antifungal agent in admixture with a tissue softening composition, wherein the tissue softening composition comprises:
- (a) about 40 wt-% urea;
- (b) about 5.5 to about 20 wt-% petrolatum or a synthetic or semi-synthetic hydrocarbon, or a semi-solid mixture thereof;
- (c) about 10 to about 20 wt-% of a liquid petrolatum or a synthetic or semi-synthetic oleaginous liquid fraction, or a mixture thereof;
- (d) about 0.25 to about 2 wt-% of a C16-18 aliphatic straight or branched chain fatty alcohol or fatty acid, or a mixture thereof;
- (e) about 1 to about 5 wt-% propylene glycol;
- (f) about 1 to about 3 wt-% glyceryl stearate;
- (g) about 0.01 to about 0.5 wt-% xanthan gum;
- and
- (h) the balance being water.
A topical antifungal composition for treating onychomycosis consisting essentially of up to 5 wt.% of an antifungal agent in admixture with a tissue softening composition, wherein the tissue softening composition comprises:
- (a) about 40 wt-% urea;
- (b) about 5.5 to about 20 wt-% petrolatum or a synthetic or semi-synthetic hydrocarbon, or a semi-solid mixture thereof;
- (c) about 10 to about 20 wt-% of a liquid petrolatum or a synthetic or semi-synthetic oleaginous liquid fraction, or a mixture thereof;
- (d) about 0.25 to about 2 wt-% of a C16-18 aliphatic straight or branched chain fatty alcohol or fatty acid, or a mixture thereof;
- (e) about 1 to about 5 wt-% propylene glycol;
- (f) about 1 to about 3 wt-% glyceryl stearate;
- (g) about 0.01 to about 0.5 wt-% xanthan gum;
- (h) about 0.05 to about 30 wt-% of a mixture of a carbomer and triethanolamine;
- and
- (i) the balance being water.
A method of treating onychomycosis comprising using a kit which consists essentially of
- (a) a first dosage form of a tissue softening composition comprising an effective amount of urea and the balance being dermatologically acceptable excipients;
- (b) a second unit dosage form of an antifungal composition comprising an antifungal agent and a pharmaceutically acceptable carrier;
- (c) an occlusive dressing;
- and
- (d) a protective gel;
- to a nail area of a patient in need thereof.
Dependencies are inferred from the claim text.