(2-Acylaminothiazole-4-yl)acetic acid derivative
AssigneeAmerican Home Products Corporation
InventorKenneth L. Kees
Life of this patent
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Abstract
This invention provides compounds of Formula I having the structure wherein R1, R2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of 6-12 carbon atoms; m=0-10; n=1-3; and p=0-10; with the proviso that m+p is less than or equal to 15; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
Claims9
A method of treating metabolic disorders mediated by insulin resistance or hyperglycemia in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure
- wherein
- R1, R2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of 6-12 carbon atoms;
- m=0-10;
- n=1-3;
- and
- p=0-10;
- with the proviso that m+p is less than or equal to 15;
- or a pharmaceutically acceptable salt thereof.
A method of treating or inhibiting type II diabetes in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure
- wherein
- R1, R2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of 6-12 carbon atoms;
- m=0-10;
- n=1-3;
- and
- p=0-10;
- with the proviso that m+p is less than or equal to 15;
- or a pharmaceutically acceptable salt thereof.
A method of modulating glucose levels in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure
- wherein
- R1, R2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of 6-12 carbon atoms;
- m=0-10;
- n=1-3;
- and
- p=0-10;
- with the proviso that m+p is less than or equal to 15;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.