Isoindolines, method of use, and pharmaceutical compositions
AssigneeCelgene Corporation
InventorsGeorge W. Muller, David I. Stirling, Roger Shen-Chu Chen
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Abstract
Substituted 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are useful in treating inflammation, inflammatory disease, autoimmune disease, and oncogenic or cancerous conditions in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline and 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.
Claims26
A method of treating inflammation, inflammatory disease or autoimmune disease in a mammal which comprises administering thereto an effective amount of a compound of the formula:
- in which R6 is hydrogen or methyl.
A method of treating an oncogenic or cancerous condition in a mammal which comprises administering thereto an effective amount of a compound of the formula:
- in which R6 is hydrogen or methyl.
Dependencies are inferred from the claim text.