Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds

A compound of formula I

• wherein
• is selected from the group consisting of pyrazinyl, furanyl, thienyl, pyridyl, pyrimidinyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, pyrazolyl, furazanyl, pyrrolyl, imidazo[2,1-b]thiazolyl, thiono[3,2-b]pyridyl, thieno[2,3-b]pyridyl, benzofurazanyl, indolyl, azaindolyl, benzimidazolyl, benzothienyl, quinolinyl, imidazolyl, thienopyridyl, quinazolinyl, thienopyrimidyl, imidazopyridyl, isoquinolinyl and 1,2,3,4-tetrahydroisoquinolinyl;
• Z is alkylenyl, —(CH2)rC(O)NR″(CH2)s—, —(CH2)SR″NC(O)(CH2)r—[, —(CH2)rNR″(CH2)s—] or —(CH2)sNR″(CH2)r—;2)r—
• R1 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aralkyl, substituted aralkyl, heteroaralkyl, substituted heteroaralkyl, R′O(CH2)x—, R′O2C(CH2)x—, R′C(O)(CH2)x—, Y1Y2NC(O)(CH2)x—, or Y1Y2N(CH2)x—;
• R′ and R″ are independently hydrogen, alkyl substituted alkyl, aryl substituted aryl, heteroaryl, substituted heteroaryl, aralkenyl, substituted aralkenyl, heteroaralkenyl, substituted heteroaralkenyl, aralkyl, substituted aralkyl, heteroaralkyl or substituted heteroaralkyl;
• R2 is hydrogen, aralkyl, substituted aralkyl, heteroaralkyl, substituted heteroaralkyl, aralkenyl, substituted aralkenyl, heteroaralkenyl, substituted heteroaralkenyl, R3R4NC(O)(CH2)x—, R3S(O)p— or R3R4NS(O)p—;
• R3 is hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, a substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroaralkyl, substituted heteroaralkyl, aralkenyl, substituted aralkenyl, heteroaralkenyl or substituted heteroaralkenyl, or R1 and R3 taken together with the —N—S(O)p— moiety or the —N—S(O)p—NR4— moiety through which R1 and R3 are linked form a 5 to 7 membered heterocyclyl or substituted heterocyclyl;
• and
• R4 is hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl heteroaralkyl or substituted heteroaralkyl, or R3 and R4 taken together with the nitrogen to which R3 and R4 are attached form a 4 to 7 membered heterocyclyl or substituted heterocycyl;
• X1 and X1a are independently selected from H, alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, heteroaryl, substituted heteroaryl, heteroaralkyl, substituted heteroaralkyl, or X1 and X1a a taken together form oxo;
• X2 and X2a are H, or taken together form oxo;
• X3 is H, hydroxy, aralkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroarallkyl or substituted heteroaralkyl, or X3 and one of X1 and X1a taken together from a 4 to 7 membered cycloalkyl;
• X4 is H, alkyl, substituted alkyl, aralkyl or substituted aralkyl;
• X5, X5a and X5b are independently selected from H, R5R6N—, (hydroxy)HN—, (alkoxy)HN—, or (amino)HN—, R7O—, R5R6NCO—, R5R6NSO2—, R7CO—, halo, cyano, nitro and R8(O)CCH2—, and when
• a bicyclic heteroaryl group, one of X5, X5a and X5b is a substituent that is alpha to a nitrogen of the distal ring of
• and is selected from the group consisting of H, hydroxy and H2N—, (alkyl and substituted lower alkyl)HN (hydroxy)HN—, (alkoxy)HN—, or (amino)HN—;
• Y1 and Y2 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroaralkyl or substituted heteroaralkyl, or Y1 and Y2 taken together with the N through which Y1 and Y2 are linked form a 4 to 7 membered heterocyclyl;
• R5 and R6 are independently H, lower alkyl or substituted lower alkyl, or one of R5 and R6 is H and the other of R5 and R6 is R8(O)CCH2— or lower acyl;
• R7 is H, lower alkyl, substituted lower alkyl, lower acyl or R8(O)CCH2—;
• R8 is H, lower alkyl, substituted lower alkyl, alkoxy or hydroxy;
• m is 0, 1, 2 or 3;
• p and r are independently 1 or 2;
• s is 0, 1 or 2;
• and x is 1, 2, 3, 4, or 5, or
• a pharmaceutically acceptable salt thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.