Pranoprofen eyedrops containing organic amine
AssigneeSanten Pharmaceutical Co., Ltd.
InventorsShogo Miyagi, Yoshihide Horibe
Life of this patent
Estimating the term…
Abstract
An ophthalmic solution containing 0.01 to 0.5 weight % of pranoprofen and 0.1 to 5.0 weight % of an organic amine, such as tromethamine or 4-(2-hydroxyethyl)-1-(2-sulfoethyl)piperazine. Such solution has a desirable stability and does not cause undue irritation when administered to eyes to treat an inflammatory disease such as keratoconjunctivitis.
Claims19
An ophthalmic solution comprising an effective ophthalmic amount of pranoprofen as an active ingredient, an amount of benzalkonium chloride effective as a preservative, and an amount of tromethamine effective to keep the solution stable and clear and lowers eye irritation, said tromethamine being in a concentration of 1 to 2.5% by weight.
A stable and clear ophthalmic solution for decreasing eye irritation comprising 0.01 to 0.5% by weight of pranoprofen, 1 to 2.5% by weight of tromethamine and 0.002 to 0.01% by weight of benzalkonium chloride, and having a pH of 6.5 to 8.5.
A stable and clear ophthalmic solution for decreasing eye irritation comprising 0.1% by weight of pranoprofen, 1 to 2.5% by weight of tromethamine and 0.005% by weight of benzalkonium chloride, and having a pH of 7.6 to 8.0.
Dependencies are inferred from the claim text.