Radioenhanced camptothecin derivative cancer treatments
AssigneeSuperGen, Inc.
InventorsHak Choy, Luigi Lenaz
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Abstract
Disclosed is a method of enhancing the therapeutic effect of radiation in a host being treated for cancer including coadministering the radiation and an orally dosed camptothecin derivative to the host being treated for cancer. Also disclosed is a method of enhancing the therapeutic effect of radiation in a host being treated for cancer including orally dosing the host being treated for cancer with a camptothecin derivative; and administering radiation at a point when a serum concentration of the camptothecin derivative in the host being treated for cancer reaches about 50% or more of the maximum concentration achieved by the oral dose.
Claims15
A method for treating a cancer patient with a combination therapy, comprising:
- administering x-ray radiation and orally dosed 9-nitrocamptothecin to a patient having a cancer sensitive to the combination therapy in a therapeutically effective amount,
- wherein the orally dosed 9-nitrocamptothecin is administered at least two hours before the x-ray radiation.
Dependencies are inferred from the claim text.