Compositions and method for treatment of acetaminophen intoxication
AssigneeInotek Corporation
InventorsAndrew L. Salzman, Jon Mabley, Csaba Szabo
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Abstract
The invention provides compositions and methods for treatment of acetaminophen intoxication using an inhibitor of xanthine oxidase that does not induce superoxide radical formation when introduced into a subject. An example of a xanthine oxidase inhibitor that can be used according to the invention is AHPP.
Claims25
A method of treating tissue injury associated with ingestion of acetaminophen in a subject, said method comprising administering to a subject in need thereof a pharmaceutically effective amount of an inhibitor of xanthine oxidase.
A method of preventing inflammation in a subject, said method comprising administering to a subject at risk thereof a pharmaceutically effective amount an inhibitor of xanthine oxidase, wherein said inhibitor does not cause superoxide radical formation when introduced into said subject.
A method of suppressing undesired free radical formation in subject, said method comprising administering to a subject in need thereof a pharmaceutically effective amount of an inhibitor of xanthine oxidase, wherein said inhibitor does not cause superoxide radical formation when introduced into said subject.
A method for treating acetaminophen intoxication in a subject, said method comprising administering to said subject a pharmaceutically effective amount an inhibitor of xanthine oxidase, wherein said inhibitor does not cause superoxide radical formation when introduced in said subject.
A method of enhancing survival in a subject subjected to acetaminophen intoxication, said method comprising administering to a subject an amount of AHPP sufficient to prolong survival of said subject.
Dependencies are inferred from the claim text.