Benzimidazolone derivatives having mixed serotonin and dopamine receptors affinity
AssigneeIngelheim Italia S.p.A.
InventorsEnzo Cereda, Maura Bignotti, Giovanni Battista Schiavi
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Abstract
Compounds of general formula (I) wherein R1, R2, R3, and R4 denote hydrogen or hydroxy with the proviso that R1, R2, R3, and R4 cannot simultaneously represent hydrogen, processes for their preparation of the compounds of general formula (I), and their use as pharmaceuticals.
Claims14
A compound of the general formula (I)
- wherein:
- R1, R2, R3, and R4 are each hydrogen or hydroxy, with the proviso that R1, R2, R3, and R4 cannot simultaneously represent hydrogen, or a physiologically acceptable acid addition salt thereof.
5-Hydroxy-1-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-1,3-dihydro benzimidazol-2-one, or a physiologically acceptable acid addition salt thereof.
6-Hydroxy-1-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-1,3-dihydro-benzimidazol-2-one, or a physiologically acceptable acid addition salt thereof.
4-Hydroxy-1-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-1,3-dihydro-benzimidazol-2-one, or a physiologically acceptable acid addition salt thereof.
7-Hydroxy-1-{2-[4-(3-trifluoromethylphenyl)piperazi-1-yl]ethyl}-1,3-dihydro-benzimidazol-2-one, or a physiologically acceptable acid addition salt thereof.
1-{2-[4-(4-Hydroxy-3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-1,3-dihydro-benzimidazol-2-one, or a physiologically acceptable acid addition salt thereof.
1-{2-[4-(3-Hydroxy-5-trifluoromethylphenyl)piperazIn-1-yl]ethyl}-1,3-dihydro-benzimidazol-2-one, or a physiologically acceptable acid addition salt thereof.
1{-2-[4-(2-Hydroxy-5-trifluoromethylphenyl)piperazin-1-yl]ethyl}-1,3-dihydro-benzimidazol-2-one, or a physiologically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.