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US 6,281,217 B1Granted
Class of piperazino substituted thiazoles
OwnerDingwei Tim Yu, Orest Taras Macina +3inventors
InventorsDingwei Tim Yu, Orest Taras Macina, Ila Sircar, Jagadish Chandra Sircar, Christopher Mark Riviello
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Abstract
Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
Claims5
A compound of the formula:
- wherein:
- Ar is selected from among pyridyl, halo substituted pyridyl and
- where R8 is hydrogen, halo, nitro, amino, trifluoromethoxy, pyrrolyl, lower alkoxy, trifluoromethyl, cyano, lower alkynyl or trimethylsilyl lower alkynyl and R9 is hydrogen, nitro, lower alkoxy or cyano;
- B is lower alkylene or lower alkynylene;
- D is N(R12R13) wherein R12 and R13, taken together, form CH2CH2N(R14) CH2CH2where R14 represents lower alkyl;
- and
- R15 is hydrogen, nitro, amino, lower alkanamido or hydroxy;
- or a nontoxic pharmacologically acceptable salt thereof.
5 more elements
A compound of the formula:
- wherein:
- R16 is hydrogen, halo, nitro, lower alkoxy, cyano, trifluoromethyl or lower alkyl;
- R17 is hydrogen, nitro, halogen or cyano;
- R12 and R13, taken together with the nitrogen to which they are bonded, form piperazino;
- and
- R20 is hydrogen or hydroxy, or a nontoxic pharmacologically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.