Therapeutic agent for glaucoma
AssigneesSanten Pharmaceutical Co., Ltd., Daiichi Pharmaceutical Co., Ltd.
InventorsShiro Mita, Eiichi Shirasawa
Life of this patent
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Abstract
A therapeutic agent for glaucoma comprises (+)-(R)-3,4-Dihydro-2-[5-methoxy-2-[3-[N-methyl-N-[2-[(3,4-methylenedioxy) phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1,4-benzothiazine or its salt as active ingredient and pharmaceutically acceptable excipients. The therapeutic agent lowers the intraocular pressure upon topical or systemic administration.
Claims15
A method for treating glaucoma which comprises administering an effective amount of a therapeutic agent for glaucoma comprising, as active ingredient, a compound of the following formula (I) or its salt:
- wherein R1 represents one or more groups selected from the group consisting of a hydrogen atom, lower alkyl groups, halogen atoms, a nitro group, a hydroxyl group, lower alkoxy groups, lower alkanoyloxy groups, an amino group, lower alkylamino groups and lower alkoxycarbonyl groups, R2 represents a hydrogen atom, a lower alkyl group or a cycloalkyl group having 3 to 6 carbon atoms, R3 represents one or more groups selected from the group consisting of a hydrogen atom, lower alkyl groups, a hydroxyl group, lower alkoxy groups, halogen atoms, a nitro group, lower alkylenedioxy groups, lower alkanoyl groups, lower alkanoyloxy groups, an amino group, lower alkylamino groups, lower alkanoylamino groups and lower alkoxycarbonyloxy groups, or a group of —(CH2)b—, R4 represents a hydrogen atom or a lower alkyl group, A and B may be the same or different from each other and each represent a lower alkylene group having 1 to 6 carbon atoms, and n represents 3 or 4, and pharmaceutically acceptable diluent and/or carrier to a patient suffering from glaucoma.
Dependencies are inferred from the claim text.