19-nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, and the intermediates of this process, their use as medicaments and compositions

A compound of formula (I):

• in which R17 and R′17 are such that:
• either R17 and R′17 together form a ketone function, an oxime function, a hydrazono function or a methylene radical,
• or R17 is a hydroxyl radical, a hydroxymethyl radical or an acyloxy radical having at most 12 carbon atoms and R′17 represents a hydrogen atom, an alkyl, alkenyl or alkynyl radical having at most 8 carbon atoms, each of these substituents being optionally substituted,
• R3 represents a hydrogen atom, a linear or branched alkyl radical or a cyclic alkyl radical having at most 8 carbon atoms or an acyl radical having at most 12 carbon atoms,
• R16 represents a hydrogen atom, a halogen atom or an alkyl radical having at most 8 carbon atoms, m has the value 0, 1 or 2,
• X, Y and Z are such that:
• X represents a methylene radical, an arylene or arylenoxy group, having at most 10 carbon atoms linked to the steroid by a carbon atom,
• Y represents a saturated or unsaturated, linear or branched aliphatic chain, containing 1 to 18 carbon atoms, optionally interrupted by an oxygen atom,
• Z represents:
• a linear or branched alkyl radical containing 1 to 8 carbon atoms and optionally substituted, or an aryl or arylalkyl radical, each of these radicals being optionally substituted, in which the alkyl radical contains at most 6 carbon atoms and the aryl radical represents a monocyclic radical containing 5 or 6 members or a radical constituted by condensed rings containing 8 to 10 members, these radicals optionally containing one or more heteroatoms chosen from oxygen, nitrogen or sulphur atoms,
• the alkyl radicals that can be represented by R′17 and Z, the alkenyl or alkynyl radicals that can represented by R′17 and the aryl or arylalkyl radicals that can be represented by Z being optionally substituted by one or more radicals chosen from the following radicals:
• halogens,
• amino, alkylamino or dialkylamino in which the alkyl radical or radicals have 1 to 4 carbon atoms,
• hydroxyl,
• free, esterified or salified carboxy,
• alkyl having 1 to 8 carbon atoms, optionally substituted by one or more halogen atoms,
• oxo, cyano, nitro, formyl,
• acyl or acyloxy having at most 12 carbon atoms,
• alkoxy or alkylthio having 1 to 4 carbon atoms,
• alkenyl or alkynyl having at most 4 carbon atoms,
• aryl as defined above,
• and the addition salts of the above.