# US 6,281,199 B1 · Method of treatment of heart disease caused by Chlamydia pneumoniae

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- Number: US 6,281,199 B1
- Document ID: US6281199B1
- Status: Granted
- Kind: B1
- Application number: 09/294,013
- Filed: 1999-04-19
- Granted: 2001-08-28
- Earliest claimed: 1996-10-18
- Assignees: Pfizer Inc.
- Inventors: Sandeep Gupta
- Web page: https://patentgrep.com/patent/US6281199B1

## CPC

- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method of combatting atherosclerosis by administering an effective amount of a macrolide antibiotic, for example an azalide such as azithromycin, optionally together with one or more pharmaceutically acceptable carriers or excipients, to a subject.

## Claims

### Claim 1

A method of treating atherosclerosis in a patient in need thereof, said method comprising administering an effective amount of azithromycin or a derivative thereof, optionally together with one or more pharmaceutically acceptable carriers or excipients, to a subject.

### Claim 2 (depends on 1)

A method claimed in claim 1 wherein a second effective amount of azithromycin is administered about one, two or three months after administration of a first effective amount of azithromycin.

### Claim 3 (depends on 2)

A method as claimed in claim 2 wherein one or more further effective amounts of azithromycin are added at intervals of one month or more.

### Claim 4 (depends on 2)

The method of claim 2 wherein one or more further effective amounts of azithromycin are added at intervals of one, two or three months after a second effective amount of azithromycin.