Aqueous suspensions of low solubility and low stability water additives
AssigneeBioLab Services, Inc.
InventorsAlan M. Yeoman, Frederick A. Grunewald, Jonathan N. Howarth, Alan D. Harrison, Brian R. Sook, Thomas Kruppa
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Abstract
A method of improving the rate of dissolution in water of low solubility compounds by combining a low solubility compound with a rheology additive that is made of platelets or particles which orient together with ionic or hydrogen bonds. The inventive method also may improve the hydrolytic stability of hydraulically unstable low solubility compounds.
Claims60
A method of improving the rate of dissolution in water of a low solubility compound, said method comprising:
- (a) combining a low solubility compound with water and a rheology additive to form an aqueous suspension comprising 1% to 80% of said low solubility compound,
- wherein said rheology additive comprises platelets or particles which orient together with ionic or hydrogen bonds to form a three-dimensional structure;
- and
- (b) adding said suspension to water and allowing the low solubility compound to dissolve in the water.
A method of improving the hydrolytic stability of a hydrolytically unstable compound, the method comprising combining a hydrolytically unstable compound with water and a rheology additive to form an aqueous suspension comprising 1% to 80% of said hydrolytically unstable compound;
- wherein said rheology additive comprises platelets or particles which orient together with ionic or hydrogen bonds to form a three-dimensional structure.
An aqueous suspension comprising 1% to 80% of a low solubility compound, 0.1 to 10% of a rheology additive, and water;
- wherein said rheology additive comprises platelets or particles that orient together with ionic or hydrogen bonds, and wherein said low solubility compound is present in an amount at least as great as the amount of rheology additive.
Dependencies are inferred from the claim text.