SH3-containing protein, DNA and uses thereof
AssigneeBoard of Trustees of the University of Arkansas
InventorsTimothy J. O'Brien, Yinxiang Wang
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Abstract
The present invention encompasses an SH3 domain-containing TADG5 protein (SEQ ID No. 1), allelic variants or functional fragments thereof, a novel TADG5 DNA segment coding for the TADG5 protein (SEQ ID No. 2), allelic variants or functional fragments thereof, chimeric cells comprising the TADG5 DNA segment, expression vectors and plasmids comprising the TADG5 DNA segment and methods for producing the TADG5 protein. The present invention further encompasses methods of using the TADG5 protein (e.g., for gene regulation, etc.).
Claims6
An isolated TADG5 protein having the amino acid sequence of SEQ ID No. 1.
A method of regulating expression of a TADG5 target gene, comprising the step of:
- contacting a cell containing said TADG5 target gene with a molecule thereby regulating the expression of said gene, wherein said molecule is selected from the group consisting of:
- a TADG5 protein or functional fragments thereof;
- single-stranded homologous oligonucleotides, wherein said homologous oligonucleotides are homologous to sequences that bind a TADG5 protein or functional fragments thereof;
- single-stranded complimentary oligonucleotides, wherein said complimentary oligonucleotides are complimentary to sequences that bind a TADG5 protein or functional fragments thereof;
- an antibody directed towards a TADG5 protein or functional fragments thereof;
- and
- an antisense RNA molecule directed towards a TADG5 transcript or functional fragments thereof.
Dependencies are inferred from the claim text.