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US 6,281,013 B1Granted
Treatment of Infertility
AssigneeNovo Nordisk A/S
InventorChristian Grøndahl
Life of this patent
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Abstract
In an in vitro fertilization method, a woman is treated with a hypothalamic hormone and/or a pituitary hormone or an agonist or antagonist thereof or an active derivative thereof for a short period of time and, thereafter, using in vitro oocyte maturation egg or eggs are retrieved from the woman and are maturated using a meiosis activating compound.
Claims21
A method for in vitro fertilization of human oocytes, comprising:
- (a) treating a female patient, within one consecutive period, with hypothalamic or pituitary hormone, or an agonist or analogue thereof, for a period of less than 7 days;
- (b) retrieving an oocyte(s) from the patient after the less than 7 day treatment period;
- (c) exposing the oocyte(s) to a meiosis activating substance (MAS), wherein in vitro oocyte maturation is achieved;
- and
- (d) fertilizing the in vitro matured oocyte(s).
2 more elements
A pharmaceutically kit for use in in vitro fertilization, comprising
- (i) 1-8 separate unit dosages for sequential daily administration of a hypothalamic hormone, an agonist, antagonist, or analogue thereof, and/or a pituitary hormone, an agonist, antagonist, or analogue thereof, and
- (ii) 1 dosage units of a MAS compound.
A method for in vitro fertilization of human oocytes, comprising:
- (a) treating a female patient, within one consecutive period, with follicle stimulating hormone (FSH), or an agonist or analogue thereof, in the absence of chorion gonadotropin and/or gonadotropin releasing hormone, for a period of less than 4 days;
- (b) retrieving an oocyte(s) from the patient after the less than 4 day treatment period;
- (c) exposing the oocyte(s) to a meiosis activating substance (MAS), wherein in vitro oocyte maturation is achieved;
- and
- (d) fertilizing the in vitro matured oocyte(s).
2 more elements
Dependencies are inferred from the claim text.