Anti-cocaine catalytic antibody

A polypeptide comprising a light chain domain which comprises a complementarity determining region 1 having the amino acid sequence RSSSGTITANNYGS (Seq ID No:

• 40), a complementarity determining region 2 having the amino acid sequence VSNNRGP (Seq ID No:
• 41) and a complementarity determining region 3 having the amino acid sequence ALWNSNHFV (Seq ID No:
• 42), interposed between appropriate framework regions, and linked to said light chain domain a heavy chain domain which comprises a complementarity determining region 1 having the amino acid sequence TYYIY (Seq ID No:
• 67), a complementarity determining region 2 having the amino acid sequence GMNPGNGVTYFNEKFKN (Seq ID No:
• 68) and a complementarity determining region 3 having the amino acid sequence VGNLFAY (Seq ID No:
• 69) interposed between appropriate framework regions, said polypeptide having a conformation suitable for degrading cocaine.

A polypeptide comprising a light chain domain which comprises a complementarity determining region 1 having the amino acid sequence RSSXSLLYXDGKTYLN (Seq ID No:

• 79), a complementarity determining region 2 having the amino acid sequence LMSTRXS (Seq ID No:
• 80) and a complementarity determining region 3 having the amino acid sequence QXFXXYPFT (Seq ID No:
• 81), interposed between appropriate human framework regions, and linked to said light chain domain a heavy chain domain which comprises a complementarity determining region 1 having the amino acid sequence SDYAWX (Seq ID No:
• 82), a complementarity determining region 2 having the amino acid sequence YIRXXXXTRYNPSLXS (Seq ID No:
• 83) and a complementarity determining region 3 having the amino acid sequence XHYYGXXX (Seq ID No:
• 84) interposed between appropriate human framework regions, said polypeptide having a conformation suitable for degrading cocaine.

A polypeptide comprising a light chain domain which comprises a complementarity determining region 1 having the amino acid sequence KSSQSLLYSDGKTYLN (Seq ID No:

• 43), a complementarity determining region 2 having the amino acid sequence LVSKLDS (Seq ID No:
• 44) and a complementarity determining region 3 having the amino acid sequence VQGYTFPLT (Seq ID No:
• 45), interposed between appropriate framework regions, and linked to said light chain domain a heavy chain domain which comprises a complementarity determining region 1 having the amino acid sequence DHWMH (Seq ID No:
• 70), a complementarity determining region 2 having the amino acid sequence TIDLSDTYTGYNQNFKG (Seq ID No:
• 71) and a complementarity determining region 3 having the amino acid sequence RGFDY (Seq ID No:
• 72) interposed between appropriate framework regions, said polypeptide having a conformation suitable for degrading cocaine.