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US 6,280,975 B1Granted
IL-6 mutein and DNA encoding thereto
AssigneeApplied Research Systems ARS Holding N.V.
InventorsMarc Ehlers, Stefan Rose-John, Joachim Grotzinger
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Abstract
The present invention relates to a new IL-6 mutein, a DNA sequence coding for it, its use in therapy as well as a pharmaceutical composition comprising it. It is a potent IL-6 antagonist and can be advantageously used as a medicament in the treatment of diseases in which IL-6 has a pathogenetic action, such as, for example, plasmocytoma/myeloma, osteoporosis and neoplastic and auotoimmune diseases.
Claims8
A polypeptide comprising the amino acid sequence of SEQ ID NO:1.
Dependencies are inferred from the claim text.