Recombinant feline coronavirus S proteins
AssigneePfizer Inc.
InventorsTimothy J. Miller, Albert Paul Reed, Sharon R. Klepfer, Nancy E. Pfeiffer, Brian T. Suiter, Elaine V. Jones
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Abstract
The present invention provides polynucleotide molecules encoding portions of the S protein from feline infectious peritonitis virus (FIPV). The present invention further provides polynucleotide molecules encoding the entire S protein or portions thereof from feline enteric coronavirus (FECV). The polynucleotide molecules of the present invention are useful as diagnostic reagents.
Claims9
A DNA molecule consisting of a nucleotide sequence selected from the group consisting of:
- (a) SEQ ID NO:
- 19;
- (b) SEQ ID NO:
- 23;
- (c) SEQ ID NO:
- 27;
- (d) SEQ ID NO:
- 29;
- (e) SEQ ID NO:
- 31;
- and
- (f) SEQ ID NO:
- 53;
- wherein said nucleotide sequence selected from (b), (c), (d), (e) and (f) is optionally fused in frame to a nucleotide sequence that encodes a fusion partner.
A DNA molecule consisting of a nucleotide sequence which encodes a peptide selected from the group consisting of FIPV or FECV S protein amino acid residue numbers 1 to about 748, 1 to 360, about 94 to about 223, 97 to 222, and about 121 to about 180.
A DNA molecule consisting of a nucleotide sequence selected from the group consisting of:
- [(l)] (a) SEQ ID NO:
- 35;
- [(m)] (b) SEQ ID NO:
- 37;
- [(n)] (c) SEQ ID NO:
- 39;
- [(o)] (d) SEQ ID NO:
- 41;
- [(p)] (e) SEQ ID NO:
- 43;
- [(q)] (f) SEQ ID NO:
- 45;
- [(r)] (g) SEQ ID NO:
- 47;
- [(s)] (h) SEQ ID NO:
- 49;
- [(t)] (i) SEQ ID NO:
- 51;
- and [(u)] (j) a nucleotide sequence from an FIPV S gene which sequence corresponds in size and position to any of sequences [(l)-(t)] (a)-(j)
An isolated DNA molecule comprising the nucleotide sequence of SEQ ID NO:31, wherein said nucleotide sequence is optionally fused in frame to a nucleotide sequence that encodes a fusion partner.
A polynucleotide molecule consisting of a nucleotide sequence selected from the group consisting of SEQ ID NOS:1-18.
Dependencies are inferred from the claim text.